Topical NSAIDs in osteoarthritis

Osteoarthritis guidelines: a progressive role for topical NSAIDs.

Osteoarthritis (OA) is a potentially debilitating disorder that can place serious limitations on patient functionality and overall quality of life. Traditionally considered a disease of the elderly, more recent perceptions of OA reveal a broad spectrum of age and disease severity among patients. Because there are no curative or disease-modifying therapies for patients with OA at present, curren...

Oral versus topical NSAIDs in rheumatic diseases: a comparison.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs worldwide and are responsible for approximately one-quarter of all adverse drug reaction reports. NSAIDs are widely prescribed for patients with rheumatic disease--a population at increased risk for serious gastrointestinal (GI) complications. Topical administration of NSAIDs offers the advantage of local...

Topical NSAIDs for acute pain: a meta-analysis

BACKGROUND A previous systematic review reported that topical NSAIDs were effective in relieving pain in acute conditions like sprains and strains, with differences between individual drugs for efficacy. More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review. METHODS Studies were identified by searching electronic databa...

Topical NSAIDs for musculoskeletal conditions. A review of the literature.

In recent years a growing number of topical nonsteroidal anti-inflammatory drugs (NSAIDs) have become available. This has been prompted in large part by the high incidence of serious gastrointestinal adverse events associated with the use of systemic NSAIDs, and the premise that minimisation of plasma concentrations of active drug may result in fewer systemic adverse effects. Evidence in humans...

Key questions concerning paracetamol and NSAIDs for osteoarthritis.